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Updated: Jul 14, 2026

Fentanyl Analog Screening using LC-TIMS-TOF MS/MS

Fentanyl Analog Screening using LC-TIMS-TOF MS/MS

Published on: November 8, 2024

[Delayed encephalopathy following acute fentanyl intoxicication].

Fumitaka Shimizu¹, Motoharu Kawai, Jun-Ichi Ogasawara

¹Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine.

Rinsho Shinkeigaku = Clinical Neurology

|June 26, 2007

Summary

An 84-year-old woman experienced acute fentanyl intoxication and delayed encephalopathy after applying a fentanyl patch with heat. Despite initial recovery, neurological symptoms reappeared but improved, suggesting a potential neuroprotective effect of fentanyl.

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Area of Science:

Toxicology
Neurology
Pharmacology

Background:

Fentanyl patches are used for pain management.
Misuse, such as applying heat, can lead to overdose.

Observation:

An 84-year-old woman developed acute fentanyl intoxication from a fentanyl patch applied to a heated knee joint.
She experienced coma, followed by delayed neurological symptoms including mutism, pyramidal signs, frontal lobe signs, and parkinsonism.

Findings:

The patient recovered from acute fentanyl intoxication but developed delayed encephalopathy.
Neurological symptoms improved significantly over 90 days without specific treatment.
Fentanyl's potential neuroprotective effect may have contributed to a milder outcome compared to similar intoxications.

Implications:

This case highlights the risks of fentanyl patch misuse and the potential for delayed neurological complications.
Fentanyl's neuroprotective properties warrant further investigation in cases of intoxication.
Understanding these effects can inform clinical management and prognosis.