Chelation therapy and vanadium: effect on reproductive organs in rats
Sadhana Shrivastava1, Anjana Jadon, Sangeeta Shukla
1Reproductive Biology and Toxicology Laboratory, School of Studies in Zoology, Jiwaji University, Gwalior 474 011, India. dr_sadhana59@rediffmail.com
Indian Journal of Experimental Biology
|June 26, 2007
Summary
Chelating agents effectively reversed vanadium toxicity in rats, restoring reproductive organ function and blood markers. Selenium and vitamin E combinations with tiron showed the most promising therapeutic effects.
Area of Science:
- Toxicology
- Biochemistry
- Reproductive Biology
Background:
- Vanadium compounds, like vanadyl sulfate, can cause significant toxicity.
- Reproductive organs and blood parameters are sensitive indicators of toxic insult.
Purpose of the Study:
- To assess the therapeutic efficacy of chelating agents against vanadium intoxication.
- To investigate the protective effects of tiron, lipoic acid, vitamin E, and selenium on reproductive organs and blood biochemistry in rats.
Main Methods:
- Male and female rats were exposed to vanadyl sulfate.
- Treatment involved tiron alone or combined with lipoic acid, vitamin E, or selenium.
- Biochemical markers in blood and reproductive tissues were analyzed.
Main Results:
- Vanadium exposure decreased fructose, alkaline phosphatase, and adenosine triphosphatase, while increasing glycogen and acid phosphatase.
- Chelation therapy, particularly tiron combined with selenium, vitamin E, or lipoic acid, significantly ameliorated these biochemical alterations.
- Lipid peroxidation, reduced glutathione, and triglyceride levels were normalized by co-treatment with antioxidants.
- Ultrastructural damage in spermatogenic stages showed recovery.
Conclusions:
- Chelating agents, especially tiron in combination with antioxidants like selenium and vitamin E, are effective in mitigating vanadium-induced toxicity.
- This therapy restores biochemical balance and improves reproductive organ health in rats exposed to vanadyl sulfate.
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