Related Experiment Video
Updated: Jul 14, 2026
05:05
Generating a Murine Orthotopic Metastatic Breast Cancer Model and Performing Murine Radical Mastectomy
Published on: November 29, 2018
Modeling metastatic breast cancer in mice
Jos Jonkers1, Patrick W B Derksen
1Division of Molecular Biology, Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. j.jonkers@nki.nl
Journal of Mammary Gland Biology and Neoplasia
|June 26, 2007
Summary
Metastatic breast cancer remains a major cause of death, with current treatments focusing on palliative care. Genetically engineered mouse models are crucial for studying breast cancer metastasis and developing new therapies.
Area of Science:
- Oncology
- Translational Medicine
- Genetics
Background:
- Metastatic breast cancer is the primary cause of mortality in patients.
- Current treatments for metastatic breast cancer are palliative, aiming to extend survival and improve quality of life.
Purpose of the Study:
- To summarize progress in modeling breast cancer invasion and metastasis.
- To highlight current developments in genetically modified mouse models for breast cancer research.
- To discuss the impact of these models on developing novel anticancer therapies.
Main Methods:
- Review of existing literature on breast cancer mouse models.
- Focus on genetically engineered mouse models (GEMMs).
- Analysis of spontaneous, carcinogen-induced, and transplantation models.
Main Results:
- GEMMs offer valuable platforms for studying breast cancer metastasis.
- These models recapitulate key aspects of human breast cancer progression.
- Advancements in GEMMs facilitate the investigation of invasion and metastatic processes.
Conclusions:
- Genetically modified mouse models are essential tools for understanding breast cancer metastasis.
- Continued development of these models holds promise for advancing innovative breast cancer therapies.
