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[Lipid peroxidation].

J Pré1

  • 1Biochimie clinique, UFR de Médecine de l'Université Paris-Nord, Bobigny, France.

Pathologie-Biologie
|September 1, 1991
PubMed
Summary

Lipid peroxidation, a process involving free radicals, is detailed, highlighting its role in diseases. Current methods for evaluating lipid peroxidation in plasma are valuable for clinical practice despite imperfections.

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Area of Science:

  • Biochemistry
  • Pathophysiology
  • Oxidative Stress

Context:

  • Lipid peroxidation is a key process in oxidative stress.
  • Understanding its mechanisms is crucial for various disease states.
  • Physiological protective mechanisms counteract lipid peroxidation.

Purpose:

  • To provide a detailed review of spontaneous lipid peroxidation.
  • To elucidate the role of lipid peroxidation in disease.
  • To discuss methods for evaluating lipid peroxidation.

Summary:

  • This review details spontaneous lipid peroxidation (initiation, propagation, termination, end-products) based on recent studies.
  • It explores the toxic effects and physiological protective mechanisms against lipid peroxidation.
  • The significance of evaluating lipid peroxidation in clinical practice, especially in plasma, is emphasized.

Impact:

  • Sheds new light on the role of lipid peroxidation in diverse disease states.
  • Highlights the clinical relevance of lipid peroxidation assessment.
  • Informs understanding of oxidative stress-related pathologies.

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