Metabolic syndrome and pulse pressure
E Mannucci1, M Monami, G Bardini
1Department of Critical Care Medicine and Surgery, Unit of Gerontology and Geriatrics, University of Florence, Florence, Italy. edmannu@tin.it
Diabetes, Obesity & Metabolism
|June 26, 2007
Summary
High pulse pressure (PP) is linked to metabolic syndrome (MS) and its components. However, this association diminishes after accounting for age and mean blood pressure, suggesting PP is not a direct marker for MS.
Area of Science:
- Cardiovascular Health
- Metabolic Disorders
- Clinical Research
Background:
- Pulse pressure (PP) is elevated in individuals with abdominal adiposity and insulin resistance.
- Previous research suggests a potential link between high PP and metabolic abnormalities.
Purpose of the Study:
- To investigate the association between high pulse pressure (PP) and metabolic syndrome (MS).
- To examine the relationship between PP and individual components of MS.
Main Methods:
- The study analyzed 1724 subjects from the FIBAR study and 1775 type 2 diabetes patients.
- Participants not on antihypertensive medication were included to isolate the PP-MS relationship.
Main Results:
- A significant correlation was observed between PP and MS in the FIBAR sample.
- PP correlated with waist circumference, fasting glucose, and triglycerides in women, and fasting glucose in men.
- These correlations lost significance after adjusting for age and mean blood pressure.
Conclusions:
- High pulse pressure shows an association with metabolic syndrome and its components.
- This association is not independent of age and mean blood pressure.
- Current data do not support high PP as a distinct alteration associated with MS.
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