Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

4.1K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.1K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.1K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.1K
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

1.2K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
1.2K
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

482
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
482
Bone Remodeling01:40

Bone Remodeling

38.7K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.7K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

3.8K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Testosterone protects from metabolic syndrome-associated lung dysfunction in a high-fat diet rabbit model.

Endocrinology·2026
Same author

In-depth Genetic and Molecular Characterization of Unilateral Coexisting Adrenal Cortical Adenoma and Carcinoma in the Context of MEN1 Syndrome.

Endocrine pathology·2026
Same author

Management of andrological disorders from childhood and adolescence to transition age: guidelines from the Italian Society of Andrology and Sexual Medicine (SIAMS) in collaboration with the Italian Society for Pediatric Endocrinology and Diabetology (SIEDP) - part-2.

Journal of endocrinological investigation·2026
Same author

Cadmium Impairs Human GnRH Neuron Development: Mechanistic Insights into Reproductive Dysfunction.

International journal of molecular sciences·2026
Same author

Protective Effect of <i>Raphanus sativus</i> Seed Extract on Damage Induced by In Vitro Incubation and Cryopreservation of Human Spermatozoa.

Antioxidants (Basel, Switzerland)·2026
Same author

Pituitary tumor-transforming gene 1 and endocrine cancers: an up-to-date review through history, current insights and future perspectives.

Endocrine-related cancer·2025

Related Experiment Video

Updated: Oct 6, 2025

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

1.0K

Testosterone supplementation and bone parameters: a systematic review and meta-analysis study.

G Corona1, W Vena2, A Pizzocaro2

  • 1Endocrinology Unit, Medical Department, Azienda Usl, Maggiore-Bellaria Hospital, Bologna, Italy.

Journal of Endocrinological Investigation
|January 18, 2022
PubMed
Summary
This summary is machine-generated.

Testosterone replacement therapy (TRT) can improve bone mineral density and reduce bone resorption in men with hypogonadism. Effects are more pronounced with longer treatment durations and in those with lower testosterone levels.

Keywords:
BoneBone mineral densityHypogonadismLate-onset hypogonadismTestosterone

More Related Videos

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head
05:55

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head

Published on: September 27, 2024

698
Author Spotlight: Enhancing Small Animal Bone Compression Testing for Research
07:52

Author Spotlight: Enhancing Small Animal Bone Compression Testing for Research

Published on: December 1, 2023

1.9K

Related Experiment Videos

Last Updated: Oct 6, 2025

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

1.0K
Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head
05:55

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head

Published on: September 27, 2024

698
Author Spotlight: Enhancing Small Animal Bone Compression Testing for Research
07:52

Author Spotlight: Enhancing Small Animal Bone Compression Testing for Research

Published on: December 1, 2023

1.9K

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Men's Health

Background:

  • The efficacy of testosterone (T) replacement therapy (TRT) for late-onset hypogonadism remains debated.
  • Bone health is a significant concern in aging men.

Purpose of the Study:

  • To evaluate the impact of TRT on bone parameters in men with hypogonadism.
  • To synthesize evidence from observational studies and randomized controlled trials (RCTs).

Main Methods:

  • Systematic review and meta-analysis of observational studies and RCTs.
  • Inclusion of 36 studies with 3103 participants.

Main Results:

  • TRT improved areal bone mineral density (aBMD) at the spine and femoral neck in observational studies.
  • Placebo-controlled RCTs showed TRT improved lumbar spine aBMD, particularly in hypogonadal men (total testosterone < 12 nM) and with longer trial durations.
  • TRT reduced bone resorption markers in observational studies but not consistently in controlled trials.

Conclusions:

  • TRT effectively inhibits bone resorption and increases bone mass, especially at the lumbar spine.
  • Longer treatment durations are crucial for observing the anabolic effects of T and estrogens on bone metabolism.