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Related Experiment Videos

Artificial oxygen carriers: a current review.

Thad Henkel-Honke1, Mark Oleck

  • 1Froedtert Hospital, Milwaulkee, Wis, USA. hhenkelhanke@wi.rr.com

AANA Journal
|June 27, 2007
PubMed
Summary
This summary is machine-generated.

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Artificial oxygen carriers, developed due to blood supply concerns, are not blood substitutes. Hemoglobin-based carriers like Hemopure and PolyHeme are in US clinical trials, with Hemopure approved in South Africa.

Area of Science:

  • Biomedical Engineering
  • Hematology
  • Pharmacology

Background:

  • Concerns regarding blood supply safety and quantity drive the development of artificial oxygen carriers.
  • Artificial oxygen carriers are designed to transport oxygen to tissues.
  • They are broadly classified into hemoglobin-based and perfluorocarbon-based types.

Purpose of the Study:

  • To review the current status of artificial oxygen carriers.
  • To highlight key products and their clinical trial progress.
  • To differentiate artificial oxygen carriers from blood substitutes.

Main Methods:

  • Review of clinical trial status for artificial oxygen carriers.
  • Examination of regulatory approvals in the US and South Africa.

Related Experiment Videos

  • Classification of oxygen carriers based on their composition (hemoglobin or perfluorocarbon).

    • Main Results:

    • No artificial oxygen carriers are currently approved for clinical use in the United States.
    • Hemopure, a hemoglobin-based oxygen carrier, is approved for use in South Africa.
    • Hemopure and PolyHeme have filed Biologic License Applications in the US; Hemopure completed Phase III trials, while PolyHeme is in Phase III trials.
    • No North American trials are currently active for perfluorocarbon-based oxygen carriers.

    Conclusions:

    • Artificial oxygen carriers are distinct from blood substitutes and face regulatory hurdles in the US.
    • Hemoglobin-based oxygen carriers show progress in clinical development, with Hemopure leading in approvals.
    • Further research and clinical trials are necessary for the widespread adoption of these technologies.