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Related Experiment Videos

Low-grade non-hodgkin lymphomas.

Richard W Tsang1, Mary K Gospodarowicz

  • 1Department of Radiation Oncology, University of Toronto, Princess Margaret Hospital, Toronto, Ontario, Canada. Richard.tsang@rmp.uhn.on.ca

Seminars in Radiation Oncology
|June 27, 2007
PubMed
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Radiation therapy offers long-term control and potential cure for low-grade B-cell lymphomas like follicular lymphoma and MALT lymphoma. While relapse can occur, radiation remains a primary treatment, especially for localized disease and gastric MALT lymphomas.

Area of Science:

  • Oncology
  • Hematology
  • Radiation Oncology

Background:

  • Low-grade non-Hodgkin lymphomas are predominantly B-cell in origin.
  • Follicular lymphoma and extranodal marginal zone lymphomas (MALT lymphomas) are common types.
  • These lymphomas are sensitive to radiation therapy.

Purpose of the Study:

  • To review the role of radiation therapy in managing low-grade B-cell lymphomas.
  • To discuss treatment outcomes and relapse patterns for follicular and MALT lymphomas.
  • To outline radiation protocols for different stages and subtypes of these lymphomas.

Main Methods:

  • Review of existing literature on radiation therapy for follicular and MALT lymphomas.
  • Analysis of treatment doses, fields, and outcomes.

Related Experiment Videos

  • Discussion of relapse patterns and palliative strategies.

    • Main Results:

    • Moderate radiation doses (30-35 Gy) achieve long-term local control and potential cure for stage I/II follicular and MALT lymphomas.
    • Involved-field radiation therapy is standard with minimal morbidity.
    • Relapse rates are significant (50% for follicular, 30-40% for non-gastric MALT) with indolent systemic progression.
    • Radiation is curative for gastric MALT lymphomas unresponsive to antibiotics.
    • Palliative low-dose radiation (4 Gy) can manage symptoms in advanced stages.

    Conclusions:

    • Radiation therapy is a highly effective primary treatment for localized low-grade follicular and MALT lymphomas.
    • While systemic relapse can occur, radiation offers durable local control and is crucial for specific indications like gastric MALT lymphoma.
    • Management strategies should consider radiation for localized disease and palliation in advanced stages.