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Complement factor h polymorphism, inflammatory mediators, and retinal vessel diameters: the rotterdam study.

Frank Jan de Jong¹, M Kamran Ikram, Dominiek D G Despriet

¹Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.

Investigative Ophthalmology & Visual Science

|June 27, 2007

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The His allele of the complement factor H (CFH) gene was not linked to larger retinal venular diameters in elderly individuals. This study found no association between the CFH Tyr402His polymorphism and retinal venular size.

Area of Science:

Ophthalmology
Genetics
Immunology

Background:

Retinal venular dilatation is a known indicator of systemic inflammation.
The complement factor H (CFH) gene plays a crucial role in inhibiting the complement pathway.

Purpose of the Study:

To investigate the association between the His allele of the Tyr402His polymorphism in the CFH gene and retinal venular diameters.
To examine potential effect modification by smoking and inflammatory markers.

Main Methods:

Cross-sectional study within the Rotterdam Study, including 5066 elderly participants (aged 55+).
Genotyping of the CFH Tyr402His polymorphism.
Grading of retinal arteriolar and venular diameters from digitized fundus transparencies.

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Main Results:

The His(402) allele was associated with smaller, not larger, retinal venular diameters (P-trend = 0.03).
This association was observed exclusively in never-smokers.
No significant modification by inflammatory markers (ESR, leukocyte count, CRP, fibrinogen) or cardiovascular risk factors was found.
No associations were detected with retinal arteriolar diameters.

Conclusions:

The study does not support the hypothesis that the His(402) allele is linked to larger retinal venular diameters.
The observed association with smaller venular diameters in never-smokers is likely a chance finding.
The CFH Tyr402His variant does not appear to be related to retinal venular diameters.