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Related Concept Videos

Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
Several...
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
Drug Dosage Regimen: Overview01:15

Drug Dosage Regimen: Overview

A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
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Related Experiment Video

Updated: Jul 14, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Medication overuse headache.

M E Lenaerts1, J R Couch

  • 1Headache Section, Department of Neurology, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA. marc-lenaerts@ouhsc.edu

Minerva Medica
|June 27, 2007
PubMed
Summary

Medication overuse headache (MOH) is a frequent cause of chronic headaches, particularly migraines, posing a significant treatment challenge. Discontinuing the overused medication is the primary therapy, alongside managing comorbidities and educating patients.

Area of Science:

  • Neurology
  • Pain Medicine

Background:

  • Medication overuse headache (MOH) is a prevalent complication of chronic headache disorders, notably migraine.
  • It presents a substantial therapeutic challenge, often dominating patient populations in specialized headache clinics.

Observation:

  • The syndrome is frequently underdiagnosed, with the impact of symptomatic medication overuse often underestimated.
  • Physician education is crucial for preventing and managing this intractable condition.

Findings:

  • The cornerstone of MOH treatment is the cessation of the overused medication.
  • A comprehensive approach includes managing psychiatric comorbidities and prioritizing patient education.

Implications:

  • Various abortive and prophylactic pharmacological treatments exist.

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Last Updated: Jul 14, 2026

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  • Further research is essential to understand MOH mechanisms and develop superior therapeutic strategies.