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Updated: Jul 14, 2026
10:23
Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice
Published on: December 1, 2017
Urinary tract diseases and bladder cancer risk: a case-control study
Manisha Jhamb1, Jie Lin, Rebecca Ballow
1Department of Epidemiology, Unit 1340, The University of Texas M.D. Anderson Cancer Center, 1155 Hermann Pressler Blvd, Houston, TX 77030, USA.
Cancer Causes & Control : CCC
|June 27, 2007
Summary
Urinary tract diseases like cystitis may increase bladder cancer risk, but frequent kidney infections appear protective. This study clarifies the complex relationship between urinary conditions and bladder cancer development.
Area of Science:
- Urology
- Oncology
- Epidemiology
Background:
- The link between urinary tract diseases and bladder cancer (BC) etiology remains unclear.
- Understanding this association is crucial for BC prevention and management.
Purpose of the Study:
- To investigate the role of prior urinary tract diseases in bladder cancer risk.
- To analyze the impact of the timing of urinary tract disease diagnosis relative to BC diagnosis.
Main Methods:
- A case-control study involving 659 BC patients and 689 controls.
- Data collected through in-person interviews.
- Logistic regression analyses to estimate BC risk associated with urinary tract diseases.
Main Results:
- History of cystitis showed increased BC risk (OR=1.52), but this was attenuated for diagnoses made over a year prior.
- Four or more kidney infections were associated with significantly decreased BC risk (OR=0.17) with a dose-response relationship.
- No significant interactions were found between smoking and various urinary tract diseases.
Conclusions:
- Urinary tract infections do not appear to be a major factor in bladder cancer development.
- The study's strength lies in analyzing diagnosis timing to mitigate detection bias.
- Findings contribute to a better understanding of urinary diseases and BC risk.
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