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Updated: Jul 14, 2026

NMR 15N Relaxation Experiments for the Investigation of Picosecond to Nanoseconds Structural Dynamics of Proteins
Published on: November 1, 2024
NMR studies of RNA dynamics and structural plasticity using NMR residual dipolar couplings
Melissa Getz1, Xiaoyan Sun, Anette Casiano-Negroni
1Department of Chemistry, The University of Michigan, Ann Arbor, MI 48109, USA.
Abstract:
An increasing number of RNAs are being discovered that perform their functions by undergoing large changes in conformation in response to a variety of cellular signals, including recognition of proteins and small molecular targets, changes in temperature, and RNA synthesis itself. The measurement of NMR residual dipolar couplings (RDCs) in partially aligned systems is providing new insights into the structural plasticity of RNA through combined characterization of large-amplitude collective helix motions and local flexibility in noncanonical regions over a wide window of biologically relevant timescales (
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