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Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
Published on: October 26, 2016
Pasty injectable biodegradable polymers derived from natural acids.
Michal Y Krasko1,2,3, Abraham J Domb1,2,3
1Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, 91120 Jerusalem, Israel.
Journal of Biomedical Materials Research. Part A
|June 28, 2007
Summary
New biodegradable polymers can be mixed with drugs at room temperature for easy injection. These pasty poly (ester-anhydride)s offer a simple way to deliver heat-sensitive medications.
Area of Science:
- Polymer Chemistry
- Biomaterials Science
- Drug Delivery Systems
Background:
- Pasty biodegradable polymers offer advantages for drug formulation and delivery, especially for heat-sensitive drugs.
- Simple preparation and room-temperature mixing are key benefits for injectable drug carriers.
- Existing materials may have limitations in terms of stability or ease of administration.
Purpose of the Study:
- To synthesize and characterize novel pasty biodegradable poly (ester-anhydride)s.
- To evaluate the potential of these polymers as injectable drug delivery carriers.
- To investigate the effect of polymer composition on thermal and mechanical properties.
Main Methods:
- Synthesis of poly (ester-anhydride)s via transesterification-repolymerization using alkanedicarboxylic acids and ricinoleic acid or its oligomers.
- Characterization using spectroscopic, chromatography, and thermal analysis techniques.
- Drug release studies and degradation analysis.
Main Results:
- Successfully synthesized biodegradable pasty poly (ester-anhydride)s with varying ratios of ricinoleic acid and dicarboxylic acids.
- Melting point and softness were influenced by the length of the methylene chain in dicarboxylic acids and the use of ricinoleic acid oligomers.
- Polymers demonstrated controlled drug release over several weeks and degraded into fatty acids.
Conclusions:
- Copolymerization of alkanedicarboxylic acids with ricinoleic acid yields pasty biodegradable polymers.
- These novel polymers are suitable for use as injectable carriers for drug delivery.
- The developed materials offer a promising platform for simple and effective administration of therapeutics.
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