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Related Concept Videos

Classification of Leukocytes01:30

Classification of Leukocytes

Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

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Related Experiment Video

Updated: Jul 14, 2026

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
09:57

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

[Large granular lymphocyte leukemia].

Estibaliz Lazaro1, Olivier Caubet, Fanny Menard

  • 1Service de médecine interne et maladies infectieuses, Centre François Magendie, Hôpital du Haut-Lévêque, Pessac. estilazaro@gmail.com

Presse Medicale (Paris, France : 1983)
|June 29, 2007
PubMed
Summary

Large granular lymphocyte (LGL) leukemia involves T-cell or NK-cell proliferation. While T-LGL leukemia is often indolent and treatable, NK-LGL leukemia can be aggressive.

Related Experiment Videos

Last Updated: Jul 14, 2026

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
09:57

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Context:

  • Large granular lymphocyte (LGL) leukemia is a rare clonal disorder.
  • It involves either cytotoxic T-cells (CD3+) or natural killer (NK) cells (CD3-).
  • Both T-LGL and NK-LGL subtypes can present as indolent or aggressive diseases.

Purpose:

  • To summarize the characteristics, diagnosis, and treatment of T-cell and NK-cell large granular lymphocyte leukemias.
  • To differentiate between the indolent nature of T-LGL and the potentially aggressive course of NK-LGL.

Summary:

  • T-LGL leukemia, often linked to autoimmune conditions like rheumatoid arthritis, typically follows an indolent course with a good prognosis.
  • NK-LGL leukemia can be more aggressive and challenging to treat.
  • Diagnosis involves flow cytometry and gene rearrangement studies for T-LGL, while KIR antibody use aids NK-LGL clonality assessment.
  • Treatment for symptomatic T-LGL focuses on immunosuppression for infections due to neutropenia.

Impact:

  • Provides a concise overview of LGL leukemia subtypes, aiding in differential diagnosis and treatment planning.
  • Highlights the distinct clinical behaviors and diagnostic approaches for T-LGL and NK-LGL.
  • Informs clinicians about current diagnostic tools and therapeutic strategies for managing LGL leukemias.