Related Experiment Video
Updated: Jul 14, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Prevalence of asthma-like symptoms in young children
Hans Bisgaard1, Stanley Szefler
1Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark. bisgaard@copsac.dk
Insights
Asthma-like symptoms like cough and wheeze affect many preschool children in the US and Europe. Current treatments are often ineffective, indicating a significant unmet clinical need for better diagnosis and management strategies.
Area of Science:
- Pediatric Respiratory Medicine
- Epidemiology of Childhood Illnesses
Background:
- Asthma-like symptoms are common in preschool children.
- The prevalence, impact, and treatment of these symptoms vary globally.
Purpose of the Study:
- To determine the prevalence, impact, and treatment of asthma-like symptoms in preschool children across the USA and Europe.
Main Methods:
- Telephone interviews were conducted with 7251 households in the USA and Europe with children aged 1-5 years.
- Data collected on recurrent cough, wheeze, or breathlessness during winter months.
Main Results:
- 32% of 9490 identified children experienced recurrent troublesome symptoms.
- 24% of symptomatic children had weekly symptoms despite treatment, impacting lifestyle and healthcare use.
- Regional differences in symptom burden, treatment, and diagnosis were observed, with higher burden in Southern Europe.
Conclusions:
- Recurrent respiratory symptoms in preschoolers are a significant cause of morbidity.
- There is a lack of international consensus on the diagnosis and treatment of these symptoms.
- This highlights a substantial unmet clinical need in preschool pediatric care.
Objective:
To determine the prevalence, impact, and treatment of asthma-like symptoms in preschool children in USA and Europe.
Study Design:
7251 households in USA and Europe with at least one child aged 1-5 years were interviewed by telephone for recurrent days troubled by cough, wheeze or breathlessness during the recent 6 winter months.
Results:
9490 young children were identified, 32% of whom were reported to suffer from recurrent days with troublesome cough, wheeze or breathlessness. Detailed interview with the 2700 mothers of the symptomatic children showed that 24% of this interview population suffered weekly symptoms despite current treatment with considerable impact on lifestyle and healthcare resource use. Antibiotics, cough- and herbal-medications were the most commonly used treatments. Anti-asthmatic and anti-allergy agents were prescribed in the order: inhaled beta2-agonists > inhaled corticosteroid > oral anti-histamines > oral corticosteroids. The reported symptom burden was higher in Southern Europe and there were pronounced regional differences in treatment and diagnostic terms.
Conclusions:
Recurrent days with cough, wheeze or breathlessness in preschool children represents a major cause of morbidity in preschool children despite current treatment. There is a striking lack of international consensus on diagnosis and treatment. This uncontrolled morbidity highlights a significant unmet clinical need in preschool children.
Related Concept Videos
Asthma III: Clinical Manifestations
Asthma-I: Introduction
Asthma-III: Symptoms and Complications
Classification of Asthma
Asthma I: Introduction
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
