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Gene expression analysis in sinonasal polyposis before and after oral corticosteroids: a preliminary investigation
William E Bolger1, Arjun S Joshi, Samuel Spear
1Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20817, USA. sinusmd@comcast.net
Objective:
To characterize gene expression in sinonasal polyps and to gain insight into change in expression after oral corticosteroid treatment.
Study Design And Methods:
Nasal polyps were obtained before and after oral corticosteroid treatment and gene expression was analyzed with a focused gene array technique.
Results:
Pretreated sinonasal polyps demonstrated high gene expression for chemokine and leukotriene receptor genes (CCR2, CCR5, CX3CL1, and LTB4R) in all patients. After treatment, the global effects of corticosteroids were evident on gene expression.
Conclusions:
Gene array techniques hold promise as a research method in sinonasal polyposis. The potential benefits, as well as the potential challenges, in using these research methods will be discussed.