Acute coronary embolism without valve thrombosis in a patient with a prosthetic mitral valve--successful percutaneous coronary intervention: a case report
Related Experiment Video
Updated: Jul 14, 2026

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
Published on: May 26, 2023
Mehmet Yazici1, Mehmet Kayrak, Yasar Turan
1Selcuk University, Cardiology Department, Konya, Turkey. myazici61@hotmail.com <myazici61@hotmail.com>
Insights
A patient experienced myocardial infarction from a mitral valve prosthesis clot, despite no visible thrombus. Prompt percutaneous coronary intervention restored blood flow, highlighting a treatment for coronary embolism.
Area of Science:
- Cardiology
- Cardiovascular Surgery
- Interventional Cardiology
Background:
- Mitral valve prostheses require adequate anticoagulation to prevent thromboembolic events.
- Suboptimal anticoagulation can lead to complications such as stroke or myocardial infarction.
Observation:
- A 44-year-old female presented with anterior myocardial infarction.
- Coronary angiography revealed left anterior descending artery occlusion, attributed to embolization from her mitral valve prosthesis.
- Despite suboptimal anticoagulation, initial echocardiography showed no prosthetic valve thrombus or dysfunction.
Findings:
- Percutaneous transluminal coronary angioplasty and stenting successfully restored coronary artery perfusion.
- The patient's chest pain resolved immediately post-intervention.
- Follow-up echocardiography, including transesophageal echocardiography, confirmed no prosthetic valve thrombus.
Implications:
- Coronary embolism can occur from prosthetic valves even without detectable thrombus or dysfunction, particularly with suboptimal anticoagulation.
- Percutaneous coronary intervention is an effective treatment for acute coronary embolism in this context.
- This case underscores the importance of vigilant anticoagulation monitoring in patients with prosthetic heart valves.
Abstract:
We present a 44-year-old female patient with anterior myocardial infarction caused by embolization from mitral valve prosthesis due to inadequate anticoagulation. The patient underwent a cardiac catheterization within the 1st hour of arrival. The angiography showed total occlusion of the left anterior descending coronary artery after the second diagonal branch. Percutaneous transluminal coronary angioplasty and stenting were performed, and coronary artery perfusion was restored. The pain disappeared completely immediately after this intervention. Transthoracic echocardiography shortly after this intervention showed normal prosthetic valve function and no thrombus. Transesophageal echocardiography performed 2 days later revealed no thrombus at the prosthetic valve. In conclusion, this case demonstrated that coronary embolism may occur even without prosthetic valve thrombus or dysfunction with suboptimal International Normalized Ratio levels, and can be successfully treated with percutaneous transluminal coronary angioplasty and stenting.
Related Concept Videos
Mitral Stenosis III: Medical Management
Acute Coronary Syndrome I: Introduction
Mitral Valve Prolapse II: Assessment and Management
Mitral Regurgitation III: Medical Management
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Acute Coronary Syndrome IV: Interprofessional Care