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Oxidative stress markers are associated with persistent atrial fibrillation
Robert B Neuman1, Heather L Bloom, Irfan Shukrullah
1Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Clinical Chemistry
|June 30, 2007
Summary
Oxidative stress markers, including DROMs, E(h) GSH, and E(h) CySH, are significantly associated with atrial fibrillation (AF). These findings suggest oxidative stress may be a valuable predictor in managing AF patients.
Area of Science:
- Cardiology
- Biochemistry
- Oxidative Stress Research
Background:
- Atrial fibrillation (AF) is linked to myocardial oxidative stress.
- Antioxidant therapies have shown antiarrhythmic potential in human studies.
- This study investigates serum oxidation and inflammation markers in individuals with and without AF.
Purpose of the Study:
- To compare serum markers of oxidative stress and inflammation in individuals with and without atrial fibrillation.
- To determine the association between specific oxidative stress markers and AF.
- To evaluate the predictive value of oxidative stress markers in AF management.
Main Methods:
- Cross-sectional, case-control study of 40 matched male participants (with or without AF).
- Quantified oxidative stress using derivatives of reactive oxidative metabolites (DROMs) and ratios of oxidized to reduced glutathione (E(h) GSH) and cysteine (E(h) CySH).
- Measured inflammatory markers: high-sensitivity C-reactive protein, interleukins 1beta and 6, and tumor necrosis factor alpha.
Main Results:
- Oxidative stress markers, but not inflammatory markers, were statistically associated with AF (P <0.05).
- Increased odds ratios for AF were observed for E(h) GSH (6.1), E(h) CySH (13.6), and DROMs (15.9).
- Multivariate analysis confirmed the significant association between AF and oxidative stress, even after correcting for confounding factors.
Conclusions:
- Serum markers of oxidative stress demonstrate a significant association with atrial fibrillation.
- These oxidative stress markers may possess predictive value for managing AF.
- Further research into antioxidant strategies for AF is warranted based on these findings.
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