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Related Experiment Videos

Pneumatosis cystoides intestinalis.

C E Yale, E Balish

    Diseases of the Colon and Rectum
    |March 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Pneumatosis cystoides intestinalis (PCI) is a rare condition. Researchers found that specific Clostridium bacteria, C. perfringens and C. tertium, can cause PCI in germfree rats, supporting a bacterial cause.

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    Area of Science:

    • Gastroenterology
    • Microbiology
    • Pathogenesis

    Background:

    • Pneumatosis cystoides intestinalis (PCI) is an uncommon gastrointestinal disease with an unknown cause.
    • It is characterized by gas-filled cysts within the intestinal wall.

    Purpose of the Study:

    • To investigate the etiology of Pneumatosis cystoides intestinalis (PCI).
    • To determine if specific bacterial species can induce PCI in a controlled environment.

    Main Methods:

    • Germfree rats were inoculated intraperitoneally with pure cultures of Clostridium bacteria.
    • Specific species tested included C. perfringens, C. tertium, and eight other Clostridia species.
    • The development of PCI was observed in the inoculated rats.

    Main Results:

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    • Pneumatosis cystoides intestinalis (PCI) was successfully induced in germfree rats by inoculating with C. perfringens or C. tertium.
    • Inoculation with eight other Clostridia species did not result in PCI formation.
    • These findings establish a bacterial theory for the pathogenesis of some PCI cases.

    Conclusions:

    • The study establishes a bacterial etiology for Pneumatosis cystoides intestinalis (PCI), implicating C. perfringens and C. tertium.
    • Treatment strategies for severe conditions associated with PCI should consider targeting potential Clostridial infections.