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Related Experiment Videos

Nanosizing--oral formulation development and biopharmaceutical evaluation.

Filippos Kesisoglou1, Santipharp Panmai, Yunhui Wu

  • 1Department of Pharmaceutical Research, Merck & Co., Inc., West Point, PA, USA. filippos_kesisoglou@merck.com

Advanced Drug Delivery Reviews
|July 3, 2007
PubMed
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Nanosizing drug particles to 100-200 nm significantly enhances their dissolution rate and oral bioavailability. This review covers nanosizing principles, formulation, and in vivo applications for poorly soluble drugs.

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery
  • Nanotechnology

Background:

  • Poor aqueous solubility is a major challenge in oral drug development, limiting bioavailability.
  • Active pharmaceutical ingredients (APIs) often exhibit insufficient dissolution rates.
  • Overcoming solubility issues is critical for effective therapeutic outcomes.

Purpose of the Study:

  • To review the principles and applications of drug nanosizing.
  • To discuss the production and characterization of nanoformulations.
  • To summarize in vivo experiences with nanosized drug formulations.

Main Methods:

  • Particle size reduction to the sub-micron (nanometer) range (100-200 nm).
  • Formulation development of nano-sized active pharmaceutical ingredients (APIs).

Related Experiment Videos

  • Characterization techniques for nanoformulations.
  • Review of in vivo studies demonstrating efficacy.

    • Main Results:

    • Nanosizing dramatically increases the surface area of APIs.
    • Enhanced surface area leads to significantly improved dissolution rates.
    • Increased dissolution rates translate to substantial bioavailability improvements.

    Conclusions:

    • Nanosizing is a key strategy to enhance oral bioavailability of poorly soluble drugs.
    • Nanoformulations offer a viable solution for overcoming solubility hurdles in drug development.
    • Further research and clinical application of nanosizing hold significant therapeutic promise.