Related Experiment Video
Updated: Jul 14, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Can evidence-based medicine implicitly rely on current concepts of disease or does it have to develop its own
Andreas Gerber1, Frieder Hentzelt, Karl W Lauterbach
1Institute of Health Economics and Clinical Epidemiology, University of Cologne, Gleueler Strasse 176-178, 50935 Cologne/Koeln, Germany. gerber@igke.de
Abstract:
Decisions in healthcare are made against the background of cultural and philosophical definitions of disease, sickness and illness. These concepts or definitions affect both health policy (macro level) and research (meso level), as well as individual encounters between patients and physicians (micro level). It is therefore necessary for evidence-based medicine to consider whether any of the definitions underlying research prior to the hierarchisation of knowledge are indeed compatible with its own epistemological principles.
Related Concept Videos
Concepts of Health and Illness
Introduction to Epidemiology
Methods of Documentation V: CBE
In CBE, healthcare professionals establish predefined standards of practice that define what constitutes...
Causality in Epidemiology
Criteria for Causality: Bradford Hill Criteria - II
Formulating and Validating Nursing Diagnosis II
Risk nursing diagnoses represent clinical judgments of an individual, family, or community more vulnerable to developing the health problem than others...