Related Experiment Video
Updated: Aug 6, 2026
07:42
Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
Chromosome 11q13 abnormalities in human cancer
1Imperial Cancer Research Fund Laboratories, Lincoln's Inn Fields, London, UK.
Cancer Cells (Cold Spring Harbor, N.Y. : 1989)
|November 1, 1991
Summary
Structural abnormalities in chromosome 11 band q13 are linked to various cancers, including breast and squamous cell carcinomas. This study examines candidate genes within this region to understand their role in tumor development.
Area of Science:
- Oncology
- Human Genetics
- Molecular Biology
Background:
- Structural abnormalities at chromosome 11 band q13 are recurrent in multiple endocrine neoplasia type 1 (MEN1), B-cell neoplasms, breast, and squamous cell carcinomas.
- These genomic alterations include allele loss, deletions, translocations, and DNA amplification, indicating the involvement of critical genes in these tumor types.
Purpose of the Study:
- To identify and characterize genes within the 11q13 region that are affected by structural abnormalities.
- To evaluate the evidence implicating these candidate genes in the tumorigenesis of various human cancers.
Main Methods:
- Literature review and analysis of existing data on genomic alterations at 11q13.
- Assessment of candidate genes within the critical region and their reported roles in cancer.
Main Results:
- Several candidate genes within the 11q13 locus have been implicated in tumorigenesis based on observed genomic perturbations.
- The specific genes and the nature of aberrations vary across different tumor types.
Conclusions:
- Characterizing genes at 11q13 is crucial for tumor classification and risk assessment.
- Further investigation into these candidate genes will enhance understanding of their specific roles in cancer development.
Related Concept Videos
01:17Karyotyping
Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated by special staining techniques that produce a particular banding pattern on each chromosome. State-of-the-art techniques make this approach even more powerful, enabling the detection of individual genes that cause disease.A Simple Chromosome Staining Technique Provides Valuable Scientific InsightSome genetic diseases can be detected by looking at...
02:30Histone Variants at the Centromere
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3 variants are also...
02:23Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
02:21Cancers Originate from Somatic Mutations in a Single Cell
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...