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Updated: Jul 14, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Novel gold(I) 7-azacoumarin complex: synthesis, structure, optical properties, and cytotoxic effects
José S Casas1, Eduardo E Castellano, María D Couce
1Departamento de Química InorgAnica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela (Galicia), Spain. qiscasas@usc.es
Abstract:
A mixture of pyridoxalrhodanine, triethylphosphinegold(I) chloride, and sodium methoxide in methanol unexpectedly afforded the azacoumarin complex [Au(TS)(PEt3)] [HTS = 5-(hydroxymethyl)-8-methyl-3-thiol-7-azacoumarin], which was characterized by X-ray diffractometry. Its crystals consist of independent molecules in which the metal atom is bound to the azacoumarin [Au-S = 2.9458(18) A] and the phosphine [Au-P = 2.262(2) A] in an almost linear arrangement [P1-Au1-S1 = 176.93(7) degrees]. The complex showed better in vitro antitumor activity than cisplatin against the cisplatin-resistant cell line A2780cis.
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