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Published on: June 6, 2025
A close link between Fas, p53 and Apaf-1 in chronic myeloid leukemia
Faris Q Alenzi1, Richard K Wyse, Waleed G Tamimi
1Department of Medical Laboratory Sciences, College of Applied Medical Sciences, King Faisal University, PO Box 2114, Dammam 31451, and Department of Molecular Pathology, Al-Hada Armed Forces Hospital, Taif, Kingdom of Saudi Arabia. falenzi@kfu.edu.sa
Abstract:
In chronic myeloid leukemia (CML) proliferation is increased and resistance to apoptosis has been proposed as a mechanism accounting for myeloid cell expansion. There is still controversy on whether apoptosis plays an important role in the regulation of myelopoiesis. This study aims to investigate whether apoptosis-related proteins play a role in the evolution of CML and to identify, the relationship between Fas, p53 and apoptosis protease activating factor (Apaf-1) in CML. We found increased p53 and Apaf-1 messenger ribonucleic acid (mRNA) in patients with CML. However, one patient, who had a p53 point mutation, showed a massive elevation of p53 mRNA during blast crisis yet, conversely, a considerable reduction in Apaf-1 mRNA and Fas mRNA. Our results show an in-vivo linkage between Fas, p53 and Apaf-1 transcription regulation. This suggests that key genes involved in apoptosis are also involved in CML disease progression.
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