Related Experiment Video
Updated: Jul 14, 2026
06:50
Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots
Published on: August 16, 2020
Mesenteric adipose tissue alterations resulting from experimental reactivated colitis
Alessandra Gambero1, Marta Maróstica, Mario José Abdalla Saad
1Clinical Pharmacology and Gastroenterology Unit, São Francisco University Medical School, Bragança Paulista, SP, Brazil. alessandragambero@saofrancisco.edu.br
Inflammatory Bowel Diseases
|July 3, 2007
Summary
Mesenteric adipose tissue responds uniquely during inflammation, with perinodal fat producing distinct adipocytokines. This site-specific response in mesenteric fat may worsen inflammatory processes.
Area of Science:
- Adipose tissue biology
- Immunometabolism
- Gastrointestinal inflammation
Background:
- Adipose tissue secretes hormones influencing immune and metabolic functions.
- Mesenteric fat abnormalities are noted in Crohn's disease, but their role in inflammation is unclear.
- Adipocytes near lymph nodes exhibit unique physiological properties.
Purpose of the Study:
- To investigate alterations in mesenteric and perinodal adipose tissue during experimental colitis.
- To analyze morphological changes, activity, and adipocytokine production in these fat depots.
Main Methods:
- Experimental colitis induced by trinitrobenzene sulfonic acid in rats.
- Evaluation of mesenteric, perinodal mesenteric, and epididymal adipose tissue.
- Analysis of adipocyte diameter, PPAR-gamma-2 expression, lipolysis, TNF-alpha, leptin, and adiponectin production.
Main Results:
- Colitis rats showed increased mesenteric fat mass but reduced adipocyte diameter.
- Mesenteric adipocytes exhibited higher basal lipolysis and TNF-alpha production.
- Perinodal adipocytes displayed altered PPAR-gamma-2, leptin, and adiponectin levels, with increased lipolysis and TNF-alpha.
Conclusions:
- Mesenteric adipose tissue exhibits a site-specific response to experimental inflammation.
- Perinodal adipose tissue maintains adipocytokine production capabilities, potentially affecting lymph node functions.
- Changes in mesenteric adipose tissue may contribute to the exacerbation of inflammatory conditions.
