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Global and regional left ventricular function improvement following successful percutaneous coronary intervention in
Mahmoud Momtahen1, Seifolah Abdi, Zahra Ojaghi
1Department of Cardiology, Shaheed Rajaie Cardiovascular Medical Center, Mellat Park, Vali-e-Asr Avenue, Tehran, Iran. Mahmoudm@rhc.ac.ir
Insights
Successful percutaneous recanalization significantly improves systolic left ventricular function and clinical outcomes in patients with coronary artery occlusions. Echocardiography showed enhanced ejection fraction and reduced wall motion score index post-procedure.
Area of Science:
- Cardiology
- Interventional Cardiology
- Cardiac Imaging
Background:
- Coronary artery occlusions significantly impair left ventricular function.
- Percutaneous recanalization aims to restore coronary blood flow and improve cardiac performance.
Purpose of the Study:
- To evaluate the impact of successful percutaneous recanalization on global and regional systolic left ventricular function.
- To assess changes in left ventricular ejection fraction and wall motion score index post-procedure.
Main Methods:
- Echocardiography was used to assess left ventricular ejection fraction and wall motion score index.
- 110 patients with coronary artery occlusions underwent successful percutaneous recanalization.
- Assessments were performed at baseline, 1 month, and 6 months post-recanalization.
Main Results:
- Left ventricular ejection fraction significantly increased from 40.7% at baseline to 50% at 1 month and 50.9% at 6 months (P<0.001).
- Wall motion score index decreased from 1.3 at baseline to 1.1 at 1 month (P<0.01), with no significant change between 1 and 6 months.
- Significant improvements in angina severity and NYHA class were observed at 6-month follow-up.
Conclusions:
- Successful percutaneous recanalization of coronary artery occlusions leads to significant improvements in left ventricular systolic function.
- Restoration of coronary patency is associated with enhanced global and regional cardiac function and better clinical outcomes.
Abstract:
This study assessed changes in global and regional systolic left ventricular function after successful percutaneous recanalization of coronary artery occlusions. A consecutive series of 110 patients with mean+/-SD age of 53.6+/-9.1 years, in whom a complete angiographic evaluation was available before angioplasty, underwent successful percutaneous recanalization of significant occlusions of coronary arteries. Left ventricular ejection fraction and wall motion score index were assessed by echocardiography at baseline, and 1, and 6 months after recanalization. Left ventricular ejection fraction increased from a mean+/-SD of 40.7+/-4.52% at baseline to 50+/-8.3% after one month (P<0.001) and to 50.9+/-8.5% after 6 months. There was no significant difference between left ventricular ejection fraction at the end of the first and the sixth month of treatment (P = NS). The wall motion score index decreased from 1.3+/-0.2 at baseline to 1.1+/-0.2 after one month (P<0.01). There was no significant difference between 1 and 6 months results. Six-month follow-up of all patients showed significant improvement in both angina severity and NYHA class. The restoration of coronary potency of occluded coronary arteries by successful percutaneous recanalization is associated with significant improvement in regional and global left ventricular function and clinical outcome.
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