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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Atrophy progression in semantic dementia with asymmetric temporal involvement: a tensor-based morphometry study.

S M Brambati1, K P Rankin, J Narvid

  • 1Memory Aging Center, UCSF Department of Neurology, San Francisco, CA 94143, USA.

Neurobiology of Aging
|July 3, 2007
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Summary

Semantic dementia (SD) variants show significant gray matter atrophy progression in both temporal lobes and beyond. This brain atrophy pattern explains the merged clinical syndrome observed in these patients.

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Area of Science:

  • Neuroimaging
  • Neurology
  • Anatomy

Background:

  • Semantic dementia (SD) presents with distinct left (LTLV) and right (RTLV) temporal lobe variants.
  • Previous studies suggest a clinical evolution towards a merged syndrome with shared deficits.
  • The anatomical progression underlying this clinical convergence remains unclear.

Purpose of the Study:

  • To longitudinally map gray matter atrophy progression in LTLV and RTLV.
  • To identify the anatomical substrates of the merged clinical syndrome in SD.

Main Methods:

  • Longitudinal T1-weighted MRI scans from 13 LTLV, 6 RTLV, and 25 controls.
  • Tensor-based morphometry (TBM) in SPM2 for voxel-wise estimation of regional tissue loss.
  • Comparison of atrophy progression between SD variants and controls over one year.

Main Results:

  • Both LTLV and RTLV exhibited significant gray matter atrophy progression in both temporal lobes.
  • Atrophy extended beyond the initially affected temporal lobe into contralateral regions.
  • LTLV also showed significant atrophy progression in ventromedial frontal and left anterior insular regions.

Conclusions:

  • Identified anatomical substrates for the clinical evolution of LTLV and RTLV into a merged syndrome.
  • Demonstrated bilateral temporal lobe atrophy progression as a key feature.
  • Highlighted additional frontal and insular involvement in LTLV progression.