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Related Experiment Video

Updated: Jul 14, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Tibolone and osteoporosis.

Gordana Lazovic¹, Ubavka Radivojevic, Verica Milosevic

¹Institute of Gynecology and Obstetrics of the Clinical Centre of Serbia, Koste Todorovica 26, 11000, Belgrade, Serbia and Montenegro. lazovicg@eunet.yu

Archives of Gynecology and Obstetrics

|July 3, 2007

Summary

Tibolone effectively increases bone mineral density (BMD) in postmenopausal women with osteopenia or osteoporosis initially. Early treatment initiation is crucial for sustained BMD benefits over time.

Related Experiment Videos

Last Updated: Jul 14, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Area of Science:

Endocrinology
Gerontology
Bone Metabolism

Background:

Postmenopausal osteoporosis and osteopenia pose significant health risks.
Hormone replacement therapy is a common treatment for bone loss.
Tibolone is a synthetic steroid used for menopausal symptom relief and bone protection.

Purpose of the Study:

To evaluate the 5-year effects of tibolone on bone mineral density (BMD) in postmenopausal women.
To compare BMD changes in women taking tibolone versus those on calcium/vitamin D alone.

Main Methods:

A 5-year prospective, observational, controlled study.
420 postmenopausal women (average age 66.4) with osteopenia/osteoporosis.
Tibolone (1.25 mg/day) vs. calcium/vitamin D supplementation.
Bone mineral density (BMD) measured annually at lumbar spine and total hip via DXA.

Main Results:

Tibolone significantly increased BMD at the spine and hip in the first two years (P < 0.001).
BMD decreased in the control group throughout the study.
While BMD tended to decline after year two in the tibolone group, it remained higher than baseline at year five (P < 0.05).

Conclusions:

Tibolone demonstrates efficacy in increasing BMD in postmenopausal women with osteopenia/osteoporosis, particularly in the initial two years.
BMD decline observed after the second year highlights the importance of early treatment initiation.
Starting tibolone therapy as early as possible maximizes sustained bone mineral density levels.