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Published on: March 6, 2018
Carcinosarcoma of the penis
R M Long1, D Galvin, M Corcoran
1Department of Urology, University College Hospital Galway, Galway, Ireland. ronanlong@hotmail.com
Irish Journal of Medical Science
|July 3, 2007
Summary
Penile carcinosarcoma, a rare biphasic tumor, presents diagnostic challenges. This case highlights its aggressive behavior and metastatic potential, emphasizing the need for careful management of this rare penile cancer.
Area of Science:
- Oncology
- Pathology
Background:
- Penile carcinosarcoma is an exceedingly rare malignancy with poorly understood biological behavior.
- This report details the second documented case of penile carcinosarcoma.
Observation:
- An 83-year-old male presented with a fungating penile mass.
- A total penectomy with perineal urethrostomy was performed.
- The patient later developed inguinal lymphadenopathy, diagnosed as squamous cell carcinoma metastasis.
Findings:
- Microscopic examination revealed a biphasic tumor with both squamous and spindle cell components.
- Immunohistochemistry confirmed epithelial markers in squamous cells and mesenchymal markers in spindle cells.
- Metastasis to inguinal lymph nodes occurred 26 months post-initial surgery.
Implications:
- This case underscores the aggressive metastatic potential of penile carcinosarcoma.
- Accurate histological and immunohistochemical characterization is crucial for diagnosis.
- The biological behavior of this rare tumor necessitates tailored treatment strategies.
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