Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 14, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Volumetric white matter abnormalities in first-episode schizophrenia: a longitudinal, tensor-based morphometry study.

Thomas J Whitford1, Stuart M Grieve, Tom F D Farrow

  • 1Brain Dynamics Centre, Acacia House, Westmead Hospital, Westmead, NSW, 2145, Australia. thomas_whitford@wmi.usyd.edu.au

The American Journal of Psychiatry
|July 4, 2007
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring the mechanisms underlying the phenomenon of inner speaking-induced suppression.

eNeuro·2026
Same author

Profiling and Mapping Quality Improvement and Patient Safety Research Frameworks: Protocol for a Scoping Review to Guide Integration.

HRB open research·2026
Same author

Neurophysiological Evidence of Motor Preparation Dysfunction during Inner Speech and its Association with Auditory Verbal Hallucinations in Schizophrenia Spectrum Disorders.

Schizophrenia bulletin·2025
Same author

Corollary Discharge Dysfunction to Inner Speech and its Relationship to Auditory Verbal Hallucinations in Patients with Schizophrenia Spectrum Disorders.

Schizophrenia bulletin·2025
Same author

Enhanced cognitive control following neurofeedback therapy in chronic treatment-resistant PTSD among refugees: a feasibility study.

Frontiers in psychiatry·2025
Same author

Neurofeedback combined with trauma counselling for treatment-resistant PTSD in adult refugees: A case series.

Psychological trauma : theory, research, practice and policy·2025

First-episode schizophrenia patients show white matter deficits at illness onset. These brain abnormalities worsen over time, suggesting a progressive pathology contributing to schizophrenia.

Area of Science:

  • Neuroimaging
  • Psychiatry
  • Neurology

Background:

  • Schizophrenia is increasingly understood as a disorder of brain connectivity.
  • Limited research exists on white matter abnormalities in early schizophrenia.
  • The progression of white matter pathology in schizophrenia remains understudied.

Purpose of the Study:

  • To investigate white matter volumetric differences in first-episode schizophrenia patients compared to healthy controls.
  • To examine the longitudinal changes in white matter over 2-3 years in these groups.

Main Methods:

  • Structural magnetic resonance imaging (MRI) scans were acquired for 41 first-episode schizophrenia patients and 47 healthy controls.
  • Voxel-based morphometry was used to assess baseline volumetric differences.

More Related Videos

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging
11:50

A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging

Published on: February 4, 2022

Related Experiment Videos

Last Updated: Jul 14, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging
11:50

A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging

Published on: February 4, 2022

  • Tensor-based morphometry was employed to analyze longitudinal white matter changes over a 2-3 year follow-up period.

    • Main Results:

    • Patients with first-episode schizophrenia displayed white matter volume deficits in frontal and temporal lobes at baseline.
    • Increased white matter volume was observed in the frontoparietal junction bilaterally in patients.
    • Schizophrenia patients showed significantly greater white matter loss in temporal regions over the follow-up period compared to controls.

    Conclusions:

    • White matter abnormalities are present at the initial symptomatic presentation of schizophrenia.
    • These abnormalities undergo further degeneration in the early years of the illness.
    • Progressive white matter degeneration may underlie the neural connectivity deficits associated with schizophrenia.