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Updated: Jul 14, 2026
26:48
Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
Published on: July 4, 2007
[Acute necrotizing encephalopathy: patient with a relapsing and lethal evolution].
Erasmo B Casella1, Victor Nudelman, Marcelo M Felix
1Hospital Israelita Albert Einstein, and Faculdade de Mediciina da Universidade de São Paulo, Brazil. erasmobc@icr.hcnet.usp.br
Arquivos De Neuro-Psiquiatria
|July 4, 2007
Summary
Acute necrotizing encephalopathy, a rare neurological disorder, presents with rapid brain lesions. This case highlights a severe presentation in an infant, leading to brain death despite initial improvement.
Area of Science:
- Neurology
- Pediatric Neurology
- Neuroimaging
Background:
- Acute necrotizing encephalopathy (ANE) is a rare neurological disorder.
- It was initially reported in Japanese children and is characterized by rapid onset.
- Key features include symmetrical brain lesions in the brainstem, cerebellum, and thalamus.
Observation:
- A 7-month-old girl experienced two episodes of rapid loss of consciousness and paresis.
- No metabolic disturbances were identified.
- Initial recovery was followed by a fulminant second episode over two days.
Findings:
- Magnetic resonance imaging (MRI) revealed symmetrical thalamic lesions.
- Additional lesions were observed in the brainstem and cerebellum.
- The patient progressed to a state of brain death.
Implications:
- This case underscores the potential severity and rapid progression of ANE in infants.
- Early recognition and understanding of ANE's imaging characteristics are crucial.
- Further research into ANE pathogenesis and treatment is warranted.
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