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Published on: February 22, 2015
[Gliomatosis cerebri: evolution to glioblastoma multiforme]
P E Jimenez Caballero1, M Mollejo Villanueva, C Marsal Alonso
1Sección de Neurología, Hospital Virgen de la Salud, Toledo. pjimenez1010j@yahoo.es
Neurologia (Barcelona, Spain)
|July 5, 2007
Summary
Gliomatosis cerebri, a rare brain disorder, can present with seizures and behavior changes. This case highlights its potential to transform into aggressive glioblastoma multiforme, emphasizing the need for vigilance.
Area of Science:
- Neuro-oncology
- Neuropathology
Background:
- Gliomatosis cerebri is a rare neoplastic disorder characterized by diffuse glial cell infiltration.
- Initial symptoms often include seizures, headaches, and behavioral changes.
Observation:
- A 38-year-old male presented with complex partial seizures and behavioral disorder.
- MRI revealed T2 hyperintense lesions consistent with gliomatosis cerebri, confirmed by biopsy.
- The patient experienced rapid clinical deterioration with subsequent glioblastoma multiforme development.
Findings:
- The case demonstrates gliomatosis cerebri as a precursor or co-existing condition with glioblastoma.
- Transformation to a higher-grade malignancy was observed over several months.
Implications:
- Gliomatosis cerebri requires consideration in the differential diagnosis of diffuse white matter lesions.
- Rapid deterioration and contrast-enhancing focal lesions suggest malignant transformation.
