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Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
Published on: November 11, 2017
Plasticity and remodeling of brain
Michael Chopp1, Yi Li, Jing Zhang
1Department of Neurology, Henry Ford Health System, 2799 West Grand Bouleverd, Detroit, MI 48202, USA. chopp@neuro.hfh.edu
Journal of the Neurological Sciences
|July 6, 2007
Summary
Neurorestorative treatments like bone marrow mesenchymal cells (MSCs) and erythropoietin (EPO) can enhance brain repair after stroke or EAE. These therapies improve neurological function and promote brain plasticity, even when started after injury onset.
Area of Science:
- Neuroscience
- Regenerative Medicine
- Immunology
Background:
- The brain possesses intrinsic restorative processes that can be stimulated to enhance neurological function after injury.
- Stroke and experimental autoimmune encephalomyelitis (EAE) are conditions characterized by neurological deficits resulting from brain injury.
Purpose of the Study:
- To investigate the efficacy of cell-based and pharmacological neurorestorative treatments in improving neurological function after stroke and EAE.
- To demonstrate the ability of these therapies to promote brain plasticity and repair.
Main Methods:
- Utilized bone marrow mesenchymal cells (MSCs) as a cell-based therapy and erythropoietin (EPO) as a pharmacological therapy.
- Administered treatments after the onset of injury in stroke models and EAE mouse models.
- Employed Magnetic Resonance Imaging (MRI) to monitor brain changes and correlate them with functional recovery.
Main Results:
- Both MSCs and EPO significantly improved neurological function in treated animals.
- Therapies initiated after injury onset were effective in promoting recovery.
- Enhanced brain plasticity and angiogenesis were observed following treatment.
- MRI monitoring successfully correlated with reduced neurological deficits.
Conclusions:
- Cell-based (MSCs) and pharmacological (EPO) neurorestorative treatments offer a promising therapeutic strategy for brain injury, including stroke and EAE.
- These treatments amplify the brain's natural repair mechanisms, leading to improved neurological function and plasticity.
- Early intervention with neurorestorative therapies, even after injury onset, can yield significant benefits.
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