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Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
The Retinoblastoma Gene01:20

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

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Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
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[Rosai-Dorfman disease].

Lionel Galicier1, Claire Fieschi, Véronique Meignin

  • 1Service d'immunopathologie clinique, Hôpital Saint-Louis, Paris. lionel.galicier@sls.aphp.fr

Presse Medicale (Paris, France : 1983)
|July 6, 2007
PubMed
Summary

Rosai-Dorfman disease, a benign histiocytic proliferation, typically presents as large lymph node masses. While often self-limiting, it can cause visceral damage and requires specific diagnostic criteria.

Area of Science:

  • Histiocytic Disorders
  • Immunopathology
  • Oncology

Context:

  • Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a rare, non-malignant proliferation of histiocytes.
  • It commonly manifests as significant lymphadenopathy, predominantly in the cervical region, but can also involve extranodal sites and cause visceral damage.

Purpose:

  • To detail the diagnostic hallmarks of Rosai-Dorfman disease.
  • To explore its association with immunological abnormalities and its prognostic implications.
  • To outline current management strategies for this condition.

Summary:

  • Diagnosis relies on characteristic histopathology showing intrasinus histiocytic proliferation with emperipolesis (lymphocytophagocytosis).
  • Histiocytes exhibit a normal activated phenotype, and associations with autoimmune cytopenias are recognized as poor prognostic indicators.

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  • While the clinical course is often favorable, significant risks arise from mass effect, necessitating expectant management in most cases.

    • Impact:

    • Provides a comprehensive overview for clinicians managing Rosai-Dorfman disease.
    • Highlights the importance of histopathological confirmation and prognostic factor assessment.
    • Informs treatment decisions, emphasizing a tailored approach for symptomatic or progressive cases.