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Sustained-release from layered matrix system comprising chitosan and xanthan gum
Thawatchai Phaechamud1, Garnpimol C Ritthidej
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakorn Pathom, Thailand. thawatchai@emial.pharm.su.sc.th
Drug Development and Industrial Pharmacy
|July 7, 2007
Summary
Chitosan and xanthan gum create sustained-release propranolol HCl tablets. This layered matrix formulation enhances drug release duration, particularly in acidic conditions, offering a promising approach for extended drug delivery.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Developing sustained-release drug delivery systems is crucial for improving therapeutic efficacy and patient compliance.
- Chitosan and xanthan gum are biocompatible polymers with potential for controlled drug release applications.
Purpose of the Study:
- To formulate and characterize sustained-release tablets of propranolol hydrochloride using chitosan and xanthan gum as matrix materials.
- To investigate the effect of polymer ratio, lactose content, and layered matrix design on drug release kinetics.
- To elucidate the drug release mechanism and the underlying interactions between the polymers.
Main Methods:
- Direct compression method for tablet preparation.
- In vitro dissolution studies in acidic media.
- Mathematical modeling (zero order, first order, Higuchi, power law) to analyze release kinetics.
- Fourier-transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC) for polymer interaction analysis.
- Scanning electron microscopy (SEM) for surface morphology evaluation.
Main Results:
- Combined chitosan and xanthan gum significantly prolonged propranolol HCl release compared to single polymers.
- Increasing lactose content enhanced drug release.
- Layered matrix design, particularly with barrier or middle layers, extended drug release duration.
- Drug release was pH-dependent, indicating potential for targeted delivery.
- FT-IR and DSC confirmed ionic interactions between chitosan and xanthan gum.
- SEM revealed a porous gel layer formation, influencing drug diffusion.
Conclusions:
- Chitosan and xanthan gum effectively form a layered matrix for sustained release of propranolol HCl.
- The developed formulation exhibits pH-dependent release and approaches zero-order kinetics.
- Ionic interactions and gel layer formation play key roles in modulating drug release.
- This approach offers a viable strategy for designing advanced sustained-release pharmaceutical dosage forms.
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