Subcutaneous (deep) granuloma annulare in children: a possible mimicker of epithelioid sarcoma

Subcutaneous granuloma annulare (SGA) is a self-limited inflammatory lesion consisting of dermal or subcutaneous nodules usually affecting children. Lower extremity involvement is the most common anatomic site. Because of the subcutaneous location, the morphological diagnosis of SGA can be challenging, and differential diagnoses are both benign and malignant processes including epithelioid sarcoma. Our article examines the clinical, histopathological, and immunohistochemical aspects of SGA in comparison to ES. We present 3 cases of SGA in children, who were initially diagnosed with ES and discuss the differential diagnoses features between SGA and ES. Because SGA can simulate ES, the awareness of this possibility is important to avoid overtreatment, like amputation, of the benign condition (SGA).