[Inguinal swelling and ankle edema after inguinal hernia operation]

Area of Science:

• Oncology
• Pathology
• Hematology

Background:

• Diffuse large B-cell lymphoma (DLBCL) is an aggressive form of Non-Hodgkin Lymphoma.
• Inguinal lymphadenopathy can present as a rapidly growing mass, necessitating accurate diagnosis.
• Histopathological evaluation of lymph node biopsies is crucial for identifying malignant lymphoma.

Observation:

• A patient presented with a fast-growing inguinal mass, leading to the diagnosis of DLBCL.
• Malignant lymphoma is identified in only one-third of suspicious inguinal lymph node investigations.
• The International Prognostic Index (IPI) score is a significant factor in DLBCL prognosis.

Findings:

• Accurate histopathological evaluation of sufficient neoplastic tissue is critical for DLBCL diagnosis and management.
• The CHOP-R chemotherapy regimen, established in 2002, has improved overall survival.
• Disease-free survival rates exceeding 50% have been observed with the CHOP-R regimen.

Implications:

• Early and accurate diagnosis of DLBCL is essential for effective treatment planning.
• Histopathological assessment guides prognostic evaluation and therapeutic strategy selection.
• Advances in chemotherapy, such as the CHOP-R regimen, have significantly enhanced patient outcomes in DLBCL.