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Updated: Jul 13, 2026
08:12
Calculating Heart Rate Variability from ECG Data from Youth with Cerebral Palsy During Active Video Game Sessions
Published on: June 5, 2019
C-reactive protein is associated with heart rate variability.
Trine Madsen1, Jeppe Hagstrup Christensen, Egon Toft
1Department of Cardiology, and Center for Cardiovascular Research, Aalborg Hospital, Arhus University Hospital, Denmark. tmadsen@dadlnet.dk
Summary
Low-grade inflammation, indicated by high-sensitivity C-reactive protein (hs-CRP), is independently associated with autonomic dysfunction, measured by heart rate variability. This finding suggests a link between inflammation and cardiac autonomic imbalance.
Area of Science:
- Cardiology
- Biomarkers
- Autonomic Nervous System
Background:
- Low-grade inflammation and autonomic dysfunction are potential risk markers for sudden cardiac death.
- Understanding their relationship is crucial for cardiovascular health assessment.
Purpose of the Study:
- To investigate the association between low-grade inflammation and autonomic dysfunction.
- To explore if C-reactive protein levels correlate with heart rate variability indices.
Main Methods:
- 269 subjects with suspected coronary heart disease underwent 24-hour Holter monitoring.
- Time-domain heart rate variability indices were analyzed.
- High-sensitivity C-reactive protein (hs-CRP) levels were measured.
Main Results:
- Higher heart rate variability (SDNN, SDNNindex, SDANN) was observed in lower hs-CRP quartiles.
- hs-CRP was an independent determinant of heart rate variability indices.
- Associations were stronger in patients with prior myocardial infarction, coronary stenoses, and in males.
Conclusions:
- C-reactive protein and heart rate variability are independently associated.
- This supports a potential link between low-grade inflammation and autonomic dysfunction.
- These findings may have implications for risk stratification in cardiovascular disease.
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