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Updated: Jul 13, 2026

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome
06:04

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome

Published on: September 27, 2024

Predictive value of associations between carotid arterial sclerosis and left ventricular diastolic dysfunction in

Yukio Mizuguchi1, Hideji Tanaka, Yoshifumi Oishi

  • 1Cardiovascular Section, Higashi Tokushima National Hospital, National Hospital Organization, Tokushima, Japan. mizuguchi@higasitokusima.hosp.go.jp

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|July 10, 2007
PubMed

Insights

Arterial stiffness, a marker of cardiovascular disease, is linked to impaired left ventricular (LV) diastolic function in patients with risk factors. Early detection using ultrasonic strain imaging is crucial for intervention.

Area of Science:

  • Cardiovascular Medicine
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Arterial stiffness is a known contributor to cardiovascular disease morbidity and mortality.
  • Limited data exist on the relationship between arterial stiffness and left ventricular (LV) diastolic function in individuals with cardiovascular risk factors.
  • Subclinical atherosclerosis assessment is vital in this population.

Purpose of the Study:

  • To investigate the association between carotid arterial stiffness and LV diastolic function.
  • To explore correlations between arterial stiffness parameters and LV diastolic function indices.
  • To identify potential markers for early detection of cardiovascular risk.

Main Methods:

  • Carotid intima-media thickness and stiffness (beta) measured via ultrasonography in 30 patients with cardiovascular risk factors.
  • LV systolic and diastolic function assessed using transmitral flow velocity, mitral annular motion velocity, and myocardial strain/strain rate imaging.
  • Comparison with an age-matched control group.

Main Results:

  • Patients exhibited greater carotid stiffness (beta) and lower peak early diastolic strain rates in LV walls compared to controls.
  • Carotid stiffness (beta) correlated with age, transmitral flow parameters, mitral annular motion velocity, and LV diastolic strain rates.
  • Early diastolic strain rates of LV walls showed a strong relationship with carotid stiffness (beta).

Conclusions:

  • LV relaxation is significantly associated with carotid arterial atherosclerosis, specifically sclerosis, in patients with cardiovascular risk factors.
  • Ultrasonic strain imaging can aid in screening for these abnormalities.
  • Early intervention strategies are supported by these findings for at-risk populations.

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