Stereochemistry of pladienolide B
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Updated: Jul 13, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Naoki Asai1, Yoshihiko Kotake, Jun Niijima
1Tsukuba Research Laboratories, Eisai Co., Ltd, Tokodai, Tsukuba, Ibaraki, Japan. n2-asai@hhc.eisai.co.jp
Abstract:
Pladienolide B is a 12-membered macrolide isolated from Streptomyces platensis Mer-11107. It showed potent in vitro and in vivo antitumor activities and is a potential lead for novel antitumor agents. The absolute configurations at ten chiral centers were determined on the basis of spectral data of pladienolide B and its chemical transformation products.
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