Jove
Visualize
Contact Us

Related Experiment Videos

Oral lipid-based formulations.

David J Hauss1

  • 1Bristol-Myers Squibb Company, Pharmaceutical Research Institute, Route 206 and Province Line Road, Princeton, New Jersey 08543-4000, USA. david.hauss@bms.com

Advanced Drug Delivery Reviews
|July 10, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Silicone oil in protein drug products and its implications for formulation stability.

Advanced drug delivery reviews·2026
Same journal

Targeted delivery of proteolysis-targeting chimeras (PROTAC) and molecular glue degraders (MGD).

Advanced drug delivery reviews·2026
Same journal

Lysosome-targeting degrader delivery system: from formulation design to biomedical applications.

Advanced drug delivery reviews·2026
Same journal

Anti-PEG antibodies in nanomedicine: Mechanisms, risks, and opportunities.

Advanced drug delivery reviews·2026
Same journal

Optimizing macrophage-targeted intracellular delivery systems for safe and effective immunotherapies.

Advanced drug delivery reviews·2026
Same journal

Light-controlled CRISPR-dCas9 epigenome editing: advanced drug-delivery strategies and oncology applications.

Advanced drug delivery reviews·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Lipid-based formulations enhance oral drug absorption for poorly soluble compounds. This review bridges the knowledge gap, detailing development, characterization, and application of these advanced pharmaceutical formulations.

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery
  • Formulation Development

Background:

  • Poor drug solubility is a major challenge in pharmaceutical development.
  • Lipid-based formulations (LBFs) are known to improve gastrointestinal absorption of poorly soluble drugs.
  • A gap exists between the understanding and practical application of LBF technology.

Purpose of the Study:

  • To provide a comprehensive summary of oral lipid-based formulations.
  • To cover physicochemical and biopharmaceutical aspects of LBF development.
  • To review lipid excipients and formulation strategies.

Main Methods:

  • Review of published literature on lipid-based formulations.
  • Analysis of physicochemical and biopharmaceutical properties.

Related Experiment Videos

  • Summary of in vitro and in vivo evaluation techniques.

    • Main Results:

    • Detailed overview of LBF development, characterization, and utilization.
    • Review of available lipid excipients and their application in formulation modalities.
    • Summary of fundamental concepts for in vitro and in vivo assessment.

    Conclusions:

    • Lipid-based formulations offer significant potential for improving oral bioavailability of poorly soluble drugs.
    • Further understanding and application of LBF technology are needed.
    • Opportunities and limitations for wider LBF adoption are discussed.