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Related Experiment Videos

Cytohistologic correlation of thyroid nodules.

Haggi Mazeh1, Nahum Beglaibter, Diana Prus

  • 1Department of Surgery, Hadassah Hebrew University Medical Center, Mount Scopus 24035 Jerusalem, Israel. hmazeh@hadassah.org.il

American Journal of Surgery
|July 10, 2007
PubMed
Summary
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Fine-needle aspiration (FNA) accurately diagnoses papillary thyroid carcinoma but has lower predictive value for follicular lesions. Benign FNA results showed a 13% false positive rate for cancer.

Area of Science:

  • Endocrinology
  • Surgical Pathology
  • Cytopathology

Background:

  • Fine-needle aspiration (FNA) is a primary diagnostic method for thyroid nodules.
  • Correlation between FNA cytology and surgical pathology is crucial for accurate diagnosis and patient management.

Purpose of the Study:

  • To evaluate the diagnostic accuracy of FNA in assessing thyroid nodules.
  • To correlate FNA cytology findings with subsequent surgical histopathology results.

Main Methods:

  • Retrospective review of 242 thyroidectomy cases between 1994 and 2004.
  • Analysis of FNA diagnoses, patient demographics, ultrasound findings, and histopathology results.

Main Results:

  • FNA diagnosed carcinoma in 89 patients, with 89% confirmed by histopathology.

Related Experiment Videos

  • Of 78 "follicular lesion" diagnoses, only 36% were malignant on histopathology.
  • 13% of 75 FNA-diagnosed benign lesions were malignant upon surgical examination.

    • Conclusions:

    • Cytologic diagnosis of papillary carcinoma via FNA is highly predictive of thyroid cancer.
    • FNA's predictive value decreases significantly for follicular lesions.
    • A notable 13% false positive rate exists for FNA diagnoses classified as benign.