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Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
Published on: February 23, 2017
Sr-substituted hydroxyapatites for osteoporotic bone replacement.
Elena Landi1, Anna Tampieri, Giancarlo Celotti
1ISTEC-CNR, Institute of Science and Technology for Ceramics, National Research Council, via Granarolo 64, 48018 Faenza (RA), Italy. elena@istec.cnr.it
Acta Biomaterialia
|July 10, 2007
Summary
Strontium-substituted hydroxyapatite (SrHA) materials were developed as bone fillers. These porous SrHA scaffolds release strontium ions over time, offering potential anti-osteoporotic effects and improved bone healing.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Bone Tissue Engineering
Background:
- Bone comprises an inorganic phase, primarily hydroxyapatite (HA).
- Osteoporosis involves bone loss, necessitating treatments that enhance bone formation or reduce resorption.
- Strontium (Sr) ions have demonstrated anti-osteoporotic properties.
Purpose of the Study:
- To synthesize and characterize strontium-substituted hydroxyapatite (SrHA) materials.
- To evaluate the in situ release of Sr ions and calcium (Ca) from SrHA.
- To assess the suitability of porous SrHA scaffolds as bone fillers or substitutes.
Main Methods:
- SrHA powder was synthesized via a neutralization route incorporating Sr ions.
- Solubility and ion release (Sr, Ca) were measured in synthetic body fluid.
- Porous SrHA scaffolds were fabricated using cellulose sponges and a sintering process.
- Compressive strength of scaffolds was determined.
Main Results:
- SrHA granules exhibited higher solubility than stoichiometric HA.
- Sustained release of Sr ions was observed over one week.
- Enhanced Ca release was noted for SrHA compared to HA.
- Porous SrHA scaffolds demonstrated a compressive strength of 4.52 MPa with 45% porosity.
Conclusions:
- SrHA materials show potential as resorbable bone fillers and substitutes.
- The in situ release of Sr ions from SrHA could provide localized anti-osteoporotic effects.
- These materials are promising for treating bone pathologies associated with Sr deficiency.
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