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Related Concept Videos

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors01:19

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors

α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are typically...
Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by the...
Oral Hypoglycemic Agents: Biguanides and Glitazones01:26

Oral Hypoglycemic Agents: Biguanides and Glitazones

Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood glucose levels...
Dipeptidyl Peptidase 4 Inhibitors01:23

Dipeptidyl Peptidase 4 Inhibitors

Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a significant...
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Exercise and Cardiovascular Response

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Hormones Regulating Blood Glucose

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Related Experiment Video

Updated: Jul 13, 2026

Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults
06:13

Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults

Published on: December 1, 2023

Effect of adding exercise to a diet containing glucomannan.

William J Kraemer1, Jakob L Vingren, Ricardo Silvestre

  • 1Department of Kinesiology, Human Performance Laboratory, University of Connecticut, Storrs, CT 06269, USA. william.kraemer@uconn.edu

Metabolism: Clinical and Experimental
|July 10, 2007
PubMed
Summary

Adding exercise to a glucomannan diet significantly improved body composition and cholesterol levels in overweight adults. While total weight loss was similar, the exercise group showed greater fat mass reduction and better cardiovascular health markers.

Related Experiment Videos

Last Updated: Jul 13, 2026

Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults
06:13

Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults

Published on: December 1, 2023

Area of Science:

  • Nutrition and Dietetics
  • Exercise Physiology
  • Cardiovascular Health

Background:

  • Overweight individuals often face challenges with weight management and associated health risks.
  • Dietary interventions like glucomannan supplementation aim to support weight loss.
  • The combined effects of diet and exercise on metabolic and physical health require further investigation.

Purpose of the Study:

  • To evaluate the impact of a total-body exercise program combined with a glucomannan-supplemented diet on weight loss.
  • To assess changes in body composition, blood parameters, and physical performance in overweight adults.
  • To determine if exercise augments the effects of a glucomannan diet.

Main Methods:

  • An 8-week intervention involving a controlled diet with 3000 mg glucomannan was administered to overweight men and women.
  • Participants were divided into two groups: one with no exercise (No-Ex) and another with a structured resistance and endurance exercise program (Ex).
  • Measurements included body mass, fat mass, blood lipids (total cholesterol, HDL-C), and physical performance tests.

Main Results:

  • Both groups experienced reductions in body mass, fat mass, and total cholesterol.
  • The exercise group demonstrated significantly greater improvements in high-density lipoprotein cholesterol (HDL-C) and the TC/HDL-C ratio.
  • Exercise enhanced fat mass reduction by 63% in men and 50% in women, and improved strength and endurance performance.

Conclusions:

  • Combining a glucomannan diet with a total-body exercise program significantly enhances body composition and cardiovascular health markers compared to diet alone.
  • Exercise plays a crucial role in improving HDL-C levels and the TC/HDL-C ratio.
  • While both interventions lead to weight loss, exercise amplifies fat mass reduction and boosts physical capacity.