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Updated: Jul 13, 2026

A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia
Published on: November 14, 2020
Astroglia: important mediators of traumatic brain injury
Candace L Floyd1, Bruce G Lyeth
1Department of Physical Medicine and Rehabilitation, Center for Glial Biology in Medicine, 547 Spain Rehabilitation Center, University of Alabama at Birmingham, Birmingham, AL 35249, USA. clfloyd@uab.edu
Abstract:
Traumatic brain injury (TBI) research to date has focused almost exclusively on the pathophysiology of injured neurons with very little attention paid to non-neuronal cells. However in the past decade, exciting discoveries have challenged this century-old view of passive glial cells and have led to a reinterpretation of the role of glial cells in central nervous system (CNS) biology and pathology. In this chapter we review several lines of evidence, indicating that glial cells, particularly astrocytes, are active partners to neurons in the brain, and summarize recent findings that detail the significance of astrocyte pathology in traumatic brain injury.
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