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Updated: Jul 13, 2026

Nerve-sparing Mid-urethral Obstruction (NeMO) in Female Small Rodents
Published on: April 25, 2017
Neuromodulation for lower urinary tract dysfunction--an update
Zahid Hussain1, Simon C W Harrison
1Department of Urology, Pinderfields General Hospital, Wakefield, UK. zahid@doctors.org.uk
Abstract:
The aim of this review is to provide an update on the use of neuromodulation using sacral nerve stimulation for the treatment of disorders of the lower urinary tract. Neuromodulation using the InterStim system (Medtronic Inc.) is now accepted as an established therapeutic option for patients with detrusor overactivity, and for women with retention or severe voiding difficulties. However, the use of nerve stimulation in modulating lower urinary tract function has to be regarded as a technique that is in its infancy. Much has yet to be learned about the mechanism by which neuromodulation exerts its effects and there is a need to better define the clinical indications for the treatment. There is also work to be done in terms of optimising stimulation delivery, both in anatomical and electronic terms.
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