Related Experiment Video

Updated: Jul 13, 2026

High Resolution 3D Imaging of the Human Pancreas Neuro-insular Network
09:54

High Resolution 3D Imaging of the Human Pancreas Neuro-insular Network

Published on: January 29, 2018

Imaging of the brain in children with type I diabetes mellitus

Sandra L Wootton-Gorges1, Nicole S Glaser

  • 1Department of Radiology, UC Davis Children's Hospital, University of California, Davis Medical Center, Sacramento, CA, USA. sandra.gorges@ucdmc.ucdavis.edu

Pediatric Radiology
|July 11, 2007
PubMed

Insights

Type 1 diabetes mellitus (DM) impacts children

Area of Science:

  • Pediatric neurology
  • Endocrinology
  • Radiology

Background:

  • Type 1 diabetes mellitus (DM) is a prevalent childhood endocrine disorder.
  • It affects multiple organ systems, with increasing focus on neurological complications.
  • Brain structure and function can be significantly impacted by type 1 DM.

Purpose of the Study:

  • To review key neuroimaging findings in pediatric patients with type 1 DM.
  • To highlight the brain's response to acute metabolic disturbances and chronic disease.
  • To discuss the spectrum of neurological effects associated with type 1 DM.

Main Methods:

  • Review of current literature on neuroimaging in type 1 DM.
  • Analysis of imaging features related to diabetic ketoacidosis and hypoglycemia.
  • Examination of imaging findings in associated syndromes and long-term structural changes.

Main Results:

  • Imaging reveals distinct brain alterations in children with type 1 DM during acute metabolic crises.
  • Specific syndromes associated with type 1 DM present with characteristic neurological imaging findings.
  • Long-term type 1 DM can lead to demonstrable structural changes in the developing brain.

Conclusions:

  • Neuroimaging is crucial for understanding and managing brain complications in pediatric type 1 DM.
  • Early detection of brain changes can inform therapeutic strategies.
  • Further research is needed to elucidate the full impact of type 1 DM on brain development and function.

More Related Videos

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure15:18

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Published on: July 30, 2009

Related Concept Videos

Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...