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Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
Published on: December 8, 2015
PET fiber fabrics modified with bioactive titanium oxide for bone substitutes.
Tadashi Kokubo1, Takahiro Ueda, Masakazu Kawashita
1Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi, Japan.
Journal of Materials Science. Materials in Medicine
|July 11, 2007
Summary
This study developed a method to coat polyethylene terephthalate (PET) fabrics with nano-sized brookite, enabling apatite formation. This modification makes PET fabrics suitable for flexible bone substitutes that integrate with living bone.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Surface Engineering
Background:
- Polyethylene terephthalate (PET) is a versatile polymer with potential for biomedical applications.
- Developing bioactive surfaces on inert polymers like PET is crucial for tissue regeneration.
- Apatite formation on material surfaces is a key indicator of bioactivity and bone integration.
Purpose of the Study:
- To develop a method for creating an apatite-forming surface on PET.
- To investigate the transformation of titanium oxide on PET under different conditions.
- To assess the potential of modified PET fabrics as bone substitutes.
Main Methods:
- PET specimens were treated with a titania solution to form amorphous titanium oxide.
- The amorphous titanium oxide was further treated with water or hydrochloric acid (HCl) solutions at elevated temperatures.
- PET fabrics underwent NaOH pre-treatment, titania solution treatment, and HCl treatment.
- Apatite formation was evaluated in simulated body fluid (SBF).
Main Results:
- Amorphous titanium oxide on PET did not form apatite in SBF.
- Water treatment transformed titanium oxide to anatase, which did not form apatite.
- 0.10 M HCl treatment at 80°C transformed titanium oxide to nano-sized brookite, which uniformly formed apatite in SBF.
- NaOH pre-treatment enhanced the adhesion of titanium oxide and apatite layers.
- Treated PET fabrics uniformly formed apatite on individual fibers in SBF.
Conclusions:
- Nano-sized brookite formation on PET surfaces is essential for apatite mineralization.
- HCl treatment is effective in transforming amorphous titanium oxide to bioactive brookite on PET.
- Modified PET fabrics show promise as flexible bone substitutes due to their ability to form apatite and integrate with bone.
