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Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
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Soluble receptor inhibits leptin transport

Hong Tu1, Abba J Kastin, Hung Hsuchou

  • 1Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA.

Journal of Cellular Physiology
|July 11, 2007
PubMed
Summary

Soluble leptin receptors block leptin from entering the brain by preventing its binding and uptake. This study shows these receptors act as antagonists, inhibiting leptin transport across the blood-brain barrier.

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