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Updated: Jul 13, 2026
Arterial Pouch Microsurgical Bifurcation Aneurysm Model in the Rabbit
Published on: May 14, 2020
A polyvinyl alcohol core coil containing basic fibroblast growth factor evaluated in rabbits with aneurysms induced
Tomoyuki Tsumoto1, Hiroyuki Matsumoto, Tomoaki Terada
1Department of Neurological Surgery, Wakayama Medical University, Wakayama, Japan. Ttsumoto@chpnet.org
Objective:
The present study evaluates the effect of a novel coil with a polyvinyl alcohol (PVA) core that delivered basic fibroblast growth factor (bFGF) to aneurysms in rabbits induced by elastase.
Methods:
PVA was processed to form small threads and inserted into the central core of a primary coil (PVA-core coil). After immersion in saline or bFGF (500 or 2000 mug/ml), PVA-core coils were implanted into elastase-induced aneurysms in rabbits in vivo. Follow-up angiography was performed 4 and 8 weeks after embolization, and the effects were histologically semiquantified according to a grading scale.
Results:
Follow-up angiography showed that the coils did not compact or protrude and that clots did not form in any group. The score of gross neck healing was significantly higher in the 8-week 2000 bFGF group than in the 8-week PVA coil group (2.7 +/- 0.6 versus 0.0 +/- 0.0, P < 0.05). The dome healing score was significantly higher in the 4-week 2000 bFGF group than that of the 4-week PVA coil group (4.0 +/- 0.0 versus 2.7 +/- 0.6, P < 0.05). Cells positive for alpha-smooth muscle actin densely accumulated in the dome of the aneurysm embolized with PVA-core coils containing bFGF.
Conclusion:
Implantation of the PVA-core coil containing bFGF accelerated tissue growth at the neck as well as in the dome of aneurysms induced by elastase in rabbits. These results suggested that PVA-core coils could prevent the recanalization of embolized aneurysms.
